Est. 2026 · Luxembourg · 3 active pipelines

Computational science for problems that matter.

We assemble frontier AI into R&D pipelines, file the IP before wet lab, and spin out the companies. Six projects across de novo enzyme design, sovereign regulatory AI, and connectome-scale neural simulation.

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Lat. 49.61° N·Long. 6.13° E
PatentLU605811·filed Apr 2026
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01What we do

A three-line method for turning frontier models into real science.

01 / DESIGN
Compose pipelines.
We compose frontier AI models (structure prediction, generative design, language) into end-to-end R&D pipelines for specific scientific problems.
02 / PROTECT
File before the lab.
We file patents before wet lab validation, protecting the design space while the experiments run. Luxembourg jurisdiction, global PCT.
03 / SPIN OUT
Build companies.
We build companies around the projects that work, license or open-source the rest, and publish preprints regardless of outcome.
02Active · In pipeline

Active projects.

Patent-filed or near · 2 pipelines
Active · Patent filed · Pre-clinical

De novo enzymes that destroy PFAS.

The first computationally designed enzyme family targeting per- and polyfluoroalkyl substance degradation. Luxembourg patent LU605811 filed April 2026; wet lab validation in planning with academic partners.

pTM 0.900· 5 lead sequences· LU605811
Preprint · Coming soon Nekazyme S.à r.l.
Fig. 01 · Active site
Active · SaaS in build

Sovereign AI for Luxembourg financial regulation.

A language model trained on the complete CSSF regulatory corpus and Luxembourg fund law, paired with a RAG-based compliance assistant. Built for the €6.3T Luxembourg fund industry on sovereign infrastructure.

1,883 CSSF docs· 8B params
Assistant · Coming soon Private beta
Fig. 02 · Knowledge graph
03In research · Pre-patent

In research.

Design stage · 2 pipelines
In research · Pipeline in build

Electron relays for de novo redox enzymes.

Marcus theory and Dutton-Moser rules encoded into a generative pipeline for designing multi-cofactor redox enzymes, the tool that makes the next generation of Nekazyme-class work possible.

Patent pending Q4 2026
Fig. 03 · Relay chain
In research · Behavioral model

Connectome-scale simulation of biological neural systems.

Building on the FlyWire connectome (139,000 neurons, full Drosophila brain) to run biologically-grounded behavioral simulation in MuJoCo. A testbed for understanding emergent intelligence without training.

91% behavioral accuracy· 139,000 neurons
Fig. 04 · Activity cloud
04Exploring · Seeking partners

Exploring.

Hunting · 2 directions
Exploring

Language models trained on global geological data.

A foundation model over borehole records, mineral surveys, and lithology maps to replace expensive geological consulting in critical-minerals exploration.

Seeking collaborators
Fig. 05 · Core sample
Exploring · Long horizon

Computational scaffolds for bone & cartilage regeneration.

A next-generation application of de novo protein design targeting osteochondral regeneration. The enzyme-design pipeline transfers directly to scaffolds, vascularization signals, and growth factor analogs: the protein-engineering layer of a decade-long regenerative medicine program.

Seeking academic partners
Fig. 06 · Trabecular lattice
05Working principles
The thesis

We pick problems where the computational stack is ninety percent complete and assemble the last ten.

We file patents before we validate, because IP protects the design space while experiments run.

We work with academic partners for wet lab validation rather than owning experimental infrastructure.

We spin out the projects that work; we open-source the ones that don't. We publish preprints regardless.

06Contact

Have a problem that needs a pipeline?

hello@bigailab.eu →